TY - JOUR T1 - Cytogenetic Biomonitoring in Buccal Mucosa Cells from Women Submitted to Chemotherapy After Mastectomy for Breast Cancer JF - Anticancer Research JO - Anticancer Res SP - 1955 LP - 1958 VL - 36 IS - 4 AU - ANA CAROLINA FLYGARE SOUZA AU - VICTOR HUGO PEREIRA DA SILVA AU - CAMILA SEIXAS AU - TANIA TEREZINHA DE OLIVEIRA SCUDELLER AU - MARIA TERESA PACE DO AMARAL AU - DANIEL ARAKI RIBEIRO Y1 - 2016/04/01 UR - http://ar.iiarjournals.org/content/36/4/1955.abstract N2 - In addition to surgery, one of the most widely applied treatments for breast cancer is chemotherapy. Chemotherapy is currently considered efficient in curing this disease; however, the therapy may induce damage to the patient's genetic material. Thus, the aim of this study was to evaluate putative cytotoxic and mutagenic effects induced by chemotherapy in women diagnosed with breast cancer. For this purpose, a cross-sectional study was carried out in 42 women, aged 18 to 70 years, allocated according to the diagnosis and stage of breast cancer treatment: control group (healthy) (n=15), chemotherapy group (n=11) and post-chemotherapy group (n=16). Cytotoxicity and mutagenicity were analyzed by the micronucleus test in buccal mucosa cells. A higher frequency (p<0.05) of micronucleated cells was detected in the chemotherapy and post-chemotherapy groups when compared to the control. A higher frequency (p<0.05) of karyorrhexis and pyknosis in the chemotherapy group was also noted. Taken together, our results indicate that chemotherapy induces mutagenicity and cytotoxicity in buccal mucosa cells of women diagnosed with breast cancer, being persistent after finishing their treatment. ER -