RT Journal Article SR Electronic T1 Immunohistochemical Expression of CCR2, CSF1R and MMP9 in Canine Inflammatory Mammary Carcinomas JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1805 OP 1813 VO 36 IS 4 A1 TERESA P. RAPOSO A1 BRENO C.B. BEIRÃO A1 ISABEL PIRES A1 JUSTINA PRADA A1 PAULA BRILHANTE A1 DAVID J. ARGYLE A1 FELISBINA L. QUEIROGA YR 2016 UL http://ar.iiarjournals.org/content/36/4/1805.abstract AB Background: Canine inflammatory mammary cancer (IMC) and its human counterpart, inflammatory breast cancer, are extremely aggressive types of cancer. Our aim was to characterize immunohistochemical expression of C-C chemokine receptor 2, colony stimulating factor 1 receptor and metalloproteinase-9 in canine IMC versus non-IMC and to analyze associations with clinicopathological variables. Materials and Methods: Immunohistochemical staining of CCR2, CSF1R and MMP9 was performed in a series of 25 IMC and 15 non-IMC tumors. Results: No differences in the expression of these biomarkers between IMC and non-IMC were observed. Distinct nuclear subcellular expression of CCR2 was observed in IMC (p<0.001). For IMC, higher CCR2 expression was associated with increased nuclear grade (p=0.037), and higher neoplastic MMP9 expression was associated with fewer mitoses (p=0.022), higher nuclear grade (p=0.047) and increased CSF1R expression (p=0.025). Conclusion: Expression of CCR2, CSF1R and MMP9 in canine IMC could contribute to increased nuclear pleomorphism, but the biological mechanisms involved warrant further investigation.