RT Journal Article SR Electronic T1 Impact of the Radiation Dose and Completion of Palliative Radiotherapy on Survival in Patients Treated for Locally Advanced Lung Cancer JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1825 OP 1828 VO 36 IS 4 A1 JANSSEN, STEFAN A1 KAESMANN, LUKAS A1 SCHILD, STEVEN E. A1 RADES, DIRK YR 2016 UL http://ar.iiarjournals.org/content/36/4/1825.abstract AB Aim: To compare three total radiation dose levels for their impact on survival in patients receiving palliative radiotherapy (RT) for locally advanced lung cancer. Patients and Methods: Radiation dose (equivalent dose in 2 Gy fractions=EQD2: 31-40 Gy vs. 41-46 Gy vs. 47-52 Gy), completion of RT as planned, plus nine factors were analyzed for survival in 125 patients. Results: On multivariate analysis, EQD2 47-52 Gy (p=0.018), completion of planned RT (p=0.002), lower T-category (p=0.027) and lower N-category (p=0.008) were positively associated with survival. Thirty-six patients (29%) could not receive the complete planned RT dose, 19% in the 31-40 Gy group, 36% in the 41-46 Gy group and 31% in the 47-52 Gy group, respectively. Six-month survival rates of these patients were 0%, 18% and 18%, respectively. Conclusion: Higher RT doses resulted in significantly better survival than lower doses. The favorable results were impaired when the planned treatment could not be completed.