TY - JOUR T1 - Discovery of Novel (Imidazo[1,2-<em>a</em>]pyrazin-6-yl)ureas as Antiproliferative Agents Targeting P53 in Non-small Cell Lung Cancer Cell Lines JF - Anticancer Research JO - Anticancer Res SP - 1621 LP - 1630 VL - 36 IS - 4 AU - MARC-ANTOINE BAZIN AU - BÉNÉDICTE ROUSSEAU AU - SOPHIE MARHADOUR AU - CHRISTOPHE TOMASONI AU - PIERRE EVENOU AU - SYLVIE PIESSARD AU - ABRAHAM J. VAISBERG AU - SANDRINE RUCHAUD AU - STÉPHANE BACH AU - CHRISTOS ROUSSAKIS AU - PASCAL MARCHAND Y1 - 2016/04/01 UR - http://ar.iiarjournals.org/content/36/4/1621.abstract N2 - A series of (imidazo[1,2-a]pyrazin-6-yl)ureas were synthesized through 6-aminoimidazo[1,2-a]pyrazine as a key intermediate. 1-(Imidazo[1,2-a]pyrazin-6-yl)-3-(4-methoxy - phenyl)urea displayed a cytostatic activity against a non-small cell lung cancer cell line and was chosen for further mechanistic studies. Growth kinetics highlighted a selective dose-dependent response of P53-mutant NSCLC-N6-L16 cell line and overexpression of TP53 gene induced by this compound. These pharmacological data suggest a promising reactivation of p53 mutant in NSCLC-N6-L16 cell line. ER -