RT Journal Article
SR Electronic
T1 Effect of Denosumab Administration on Lumbar Vertebral Strength of Patients with Vertebral Bony Metastases: Preliminary Study
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1027
OP 1031
VO 36
IS 3
A1 KATSUHISA KAWANAMI
A1 NORIMITSU WAKAO
A1 KENTA MUROTANI
A1 MITSUHIRO KAMIYA
A1 MIKINOBU TAKEUCHI
A1 ATSUHIKO HIRASAWA
A1 TOSHIHIRO MATSUO
A1 KEIJI SATO
A1 MASATAKA DEIE
YR 2016
UL http://ar.iiarjournals.org/content/36/3/1027.abstract
AB The purpose of this study was to examine the usefulness of administration of denosumab (antibody against tumor necrosis factor superfamily member 11) as a preventative therapy for skeletal-related events (SREs), such as fracture or paralysis, by computed-tomography (CT)-based on the finite element method (FEM). Patients who had undergone treatment for vertebral metastases with denosumab administration from December 2013 to August 2015 at our Institution were reviewed. We investigated patient data at the time before denosumab administration and at 1, 3 and 6 months using CT. A total of six patients were eligible; four males and two females, with ages ranging from 35 to 73 years, with a mean age of 56 years. Repeated measures analysis of variance showed a significant increase (p=0.0055, F=10.67). To our knowledge, this is the first article to substantiate the effects of the SRE-preventative drug denosumab.