TY - JOUR T1 - Effect of Denosumab Administration on Lumbar Vertebral Strength of Patients with Vertebral Bony Metastases: Preliminary Study JF - Anticancer Research JO - Anticancer Res SP - 1027 LP - 1031 VL - 36 IS - 3 AU - KATSUHISA KAWANAMI AU - NORIMITSU WAKAO AU - KENTA MUROTANI AU - MITSUHIRO KAMIYA AU - MIKINOBU TAKEUCHI AU - ATSUHIKO HIRASAWA AU - TOSHIHIRO MATSUO AU - KEIJI SATO AU - MASATAKA DEIE Y1 - 2016/03/01 UR - http://ar.iiarjournals.org/content/36/3/1027.abstract N2 - The purpose of this study was to examine the usefulness of administration of denosumab (antibody against tumor necrosis factor superfamily member 11) as a preventative therapy for skeletal-related events (SREs), such as fracture or paralysis, by computed-tomography (CT)-based on the finite element method (FEM). Patients who had undergone treatment for vertebral metastases with denosumab administration from December 2013 to August 2015 at our Institution were reviewed. We investigated patient data at the time before denosumab administration and at 1, 3 and 6 months using CT. A total of six patients were eligible; four males and two females, with ages ranging from 35 to 73 years, with a mean age of 56 years. Repeated measures analysis of variance showed a significant increase (p=0.0055, F=10.67). To our knowledge, this is the first article to substantiate the effects of the SRE-preventative drug denosumab. ER -