RT Journal Article
SR Electronic
T1 Clinical Outcomes of Patients with Extensive Peritoneal Carcinomatosis Following Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1033
OP 1040
VO 36
IS 3
A1 YEQIAN HUANG
A1 NAYEF A. ALZAHRANI
A1 TERENCE C. CHUA
A1 YA RUTH HUO
A1 DAVID L. MORRIS
YR 2016
UL http://ar.iiarjournals.org/content/36/3/1033.abstract
AB Aim: The aims of this study were to explore clinical outcomes and assess the learning curve for cytoreductive surgery and perioperative intraperitoneal chemotherapy (PIC) for patients with a high peritoneal cancer index (PCI). Patients and Methods: This was a retrospective study of patients with a PCI of 20 or more following CRS and PIC. Outcomes in five successive groups based on the operation date were analyzed. Results: Three hundred and five patients were included in the study. The median overall survival (OS) was 89.3 months (95% confidence interval=58.9-107.6 months). OS at 1, 3 and 5 years of our study cohort was 89.4%, 70.4% and 57.5%, respectively. In terms of the learning curve, the mean duration of operation and hospital mortality decreased (p<0.001 and p=0.006 respectively). A trend for decreasing intensive care unit stay (p=0.497), high dependency unit stay (p=0.042) and total hospital stay (p=0.202) were also recorded. Conclusion: A high PCI alone should not be a contraindication for cytoreductive surgery and PIC in specialized centres.