TY - JOUR T1 - Clinical Outcomes of Patients with Extensive Peritoneal Carcinomatosis Following Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy JF - Anticancer Research JO - Anticancer Res SP - 1033 LP - 1040 VL - 36 IS - 3 AU - YEQIAN HUANG AU - NAYEF A. ALZAHRANI AU - TERENCE C. CHUA AU - YA RUTH HUO AU - DAVID L. MORRIS Y1 - 2016/03/01 UR - http://ar.iiarjournals.org/content/36/3/1033.abstract N2 - Aim: The aims of this study were to explore clinical outcomes and assess the learning curve for cytoreductive surgery and perioperative intraperitoneal chemotherapy (PIC) for patients with a high peritoneal cancer index (PCI). Patients and Methods: This was a retrospective study of patients with a PCI of 20 or more following CRS and PIC. Outcomes in five successive groups based on the operation date were analyzed. Results: Three hundred and five patients were included in the study. The median overall survival (OS) was 89.3 months (95% confidence interval=58.9-107.6 months). OS at 1, 3 and 5 years of our study cohort was 89.4%, 70.4% and 57.5%, respectively. In terms of the learning curve, the mean duration of operation and hospital mortality decreased (p<0.001 and p=0.006 respectively). A trend for decreasing intensive care unit stay (p=0.497), high dependency unit stay (p=0.042) and total hospital stay (p=0.202) were also recorded. Conclusion: A high PCI alone should not be a contraindication for cytoreductive surgery and PIC in specialized centres. ER -