PT  - JOURNAL ARTICLE
AU  - YEQIAN HUANG
AU  - NAYEF A. ALZAHRANI
AU  - TERENCE C. CHUA
AU  - YA RUTH HUO
AU  - DAVID L. MORRIS
TI  - Clinical Outcomes of Patients with Extensive Peritoneal Carcinomatosis Following Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy
DP  - 2016 Mar 01
TA  - Anticancer Research
PG  - 1033--1040
VI  - 36
IP  - 3
4099  - http://ar.iiarjournals.org/content/36/3/1033.short
4100  - http://ar.iiarjournals.org/content/36/3/1033.full
SO  - Anticancer Res2016 Mar 01; 36
AB  - Aim: The aims of this study were to explore clinical outcomes and assess the learning curve for cytoreductive surgery and perioperative intraperitoneal chemotherapy (PIC) for patients with a high peritoneal cancer index (PCI). Patients and Methods: This was a retrospective study of patients with a PCI of 20 or more following CRS and PIC. Outcomes in five successive groups based on the operation date were analyzed. Results: Three hundred and five patients were included in the study. The median overall survival (OS) was 89.3 months (95% confidence interval=58.9-107.6 months). OS at 1, 3 and 5 years of our study cohort was 89.4%, 70.4% and 57.5%, respectively. In terms of the learning curve, the mean duration of operation and hospital mortality decreased (p<0.001 and p=0.006 respectively). A trend for decreasing intensive care unit stay (p=0.497), high dependency unit stay (p=0.042) and total hospital stay (p=0.202) were also recorded. Conclusion: A high PCI alone should not be a contraindication for cytoreductive surgery and PIC in specialized centres.