TY - JOUR T1 - Vitamin D Status in Chronic Kidney Disease – UVB Irradiation Is Superior to Oral Supplementation JF - Anticancer Research JO - Anticancer Res SP - 1397 LP - 1401 VL - 36 IS - 3 AU - ROLFDIETER KRAUSE AU - HEINZ JÜRGEN ROTH AU - HEINRICH KAASE AU - RAINER STANGE AU - MICHAEL F. HOLICK Y1 - 2016/03/01 UR - http://ar.iiarjournals.org/content/36/3/1397.abstract N2 - Background: In chronic kidney disease (CKD) a deficiency of 1,25-dihydroxyvitamin D is common. The aim of this review was to compare vitamin D status after oral supplementation of vitamin D3 to that of serial suberythemal irradiation in end-stage kidney disease (ESKD) patients. Patients and Methods: Ninety-five patients, with a mean age of 62 (range=35-82) years, were treated with a mean dose of 35,000 (20,000–60,000) IU vitamin D3 per week for a period of 18 months. Fourteen patients, with a mean age of 51 (range=41-57) years, were whole-body UVB irradiated for over 6 months. From 3 hemodialysis patients skin biopsies were performed. Results: With oral supplementation 25(OH)D3 increased by 60%. With UV irradiation 25(OH)D3 increased by 400%. Gene expression analysis demonstrated an improvement in the vitamin D receptor (VDR) by 0.65 fold, in 1-alpha-hydroxylase (CYP27B1) by 1.0 fold, and in 25-hydroxylase (CYP2R) by 1.2 fold. Conclusion: Serial suberythemal UVB irradiation of patients with CKD on dialysis is capable to improve serum 25(OH)D3 and 1,25(OH)2D3 by enhancing the skin's ability to activate vitamin D. ER -