RT Journal Article
SR Electronic
T1 Expression Pattern of CDX2, Estrogen and Progesterone Receptors in Primary Gastroenteropancreatic Neuroendocrine Tumors and Metastases
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 921
OP 924
VO 36
IS 3
A1 ZIMMERMANN, NADINE
A1 LAZAR-KARSTEN, PAMELA
A1 KECK, TOBIAS
A1 BILLMANN, FRANCK
A1 SCHMID, SEBASTIAN
A1 BRABANT, GEORG
A1 THORNS, CHRISTOPH
YR 2016
UL http://ar.iiarjournals.org/content/36/3/921.abstract
AB Background: A significant number of patients with gastroenteropancreatic neuroendocrine tumors (GEP NETs) present with metastatic disease and with unknown primary in about 15% of cases. Materials and Methods: We analyzed 163 primaries of GEP NET and 115 metastases for expression of caudal type homebox 2 (CDX2), estrogen receptor (ER), progesterone receptor (PR), somatostatin receptor 2a (SSTR2a) and Ki67. Results: PR was most often positive in pancreatic NET and only rarely in non-pancreatic NET (p<0.001). ER was more frequently expressed in non-pancreatic NET (p<0.001) and was more often positive in females than males (p=0.019). CDX2 was positive in all primaries of the duodenum, ileum and appendix, but was also detected in 24% of metastases with pancreatic primary. SSTR2a and Ki67 did not differ significantly between primaries and metastases. Conclusion: Our data substantiate the value of PR, ER and CDX2 in GEP NET, and steroid hormone receptors, being differentially expressed in male and female patients. Differences between primaries and metastases were small but potentially relevant.