%0 Journal Article %A GUANGDONG QIAO %A YIZI CONG %A HAIDONG ZOU %A JUN LIN %A XINGMIAO WANG %A XIAOHUI LI %A YALUN LI %A SHIGUANG ZHU %T False-negative Frozen Section of Sentinel Lymph Node Biopsy in a Chinese Population with Breast Cancer %D 2016 %J Anticancer Research %P 1331-1337 %V 36 %N 3 %X Aim: This study aimed to investigate the accuracy of frozen section (FS) in diagnosis of sentinel lymph node metastasis and to analyze the predictive factors for false-negativity. Patients and Methods: Patients with breast cancer and clinically negative axillary were recruited for sentinel lymph node biopsy (SLNB). All nodes were examined by intraoperative FS and underwent further paraffin sectioning. Results: A total of 1,272 patients underwent SLNB over an 8-year period, and 53 patients had false-negative FS. Univariate and multivariate analysis revealed that younger age, stellate mammographic pattern, and ER-positive status were statistically different when compared to the 53 members of the cohort who were truly negative on SLNB (control group). Eight patients were lost to clinical follow-up; the recurrence-free survival rate of the remaining 49 patients with false-negative SLNB did not differ from that of the 49-patient cohort (control group) (p=0.072), while these patients did experience poorer overall survival (p=0.035). Conclusion: Younger age, stellate mammographic pattern and ER-positive status were independent predictors for false-negative FS on biopsy. %U https://ar.iiarjournals.org/content/anticanres/36/3/1331.full.pdf