RT Journal Article SR Electronic T1 A Biomarker Panel Increases the Diagnostic Performance for Epithelial Ovarian Cancer Type I and II in Young Women JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 957 OP 965 VO 36 IS 3 A1 PIA LEANDERSSON A1 GRIGORIOS KALAPOTHARAKOS A1 EMIR HENIC A1 HENRIK BORGFELDT A1 MAX PETZOLD A1 GUNILLA HØYER-HANSEN A1 CHRISTER BORGFELDT YR 2016 UL http://ar.iiarjournals.org/content/36/3/957.abstract AB Background/Aim: To assess preoperative blood levels of a biomarker panel in relation to the new classification system of epithelial ovarian cancer (EOC) type I and II. Patients and Methods: Preoperative plasma levels of B7-family protein homolog 4 (B7-H4), intact and cleaved soluble urokinase plasminogen activator receptor (suPAR), human epididymis protein 4 (HE4) and cancer antigen 125 (CA125) were analyzed in 350 patients with adnexal lesions. Results: The levels of suPAR(II-III), HE4, CA125 were all higher in EOC II than in EOC I, borderline and benign ovarian tumors. B7-H4 was increased in EOC II compared with benign ovarian tumors. The combination of suPAR(II-III), HE4, CA125 and age in premenopausal women discriminates EOC and borderline tumors from benign tumors to higher accuracy compared to the Risk of Ovarian Malignancy Algorithm (p=0.007). Conclusion: The biomarker panel suPAR(II-III), HE4, CA125 and age in premenopausal women improved discrimination of malignant and benign ovarian tumors. The plasma levels of B7-H4 were increased in patients with EOC II compared to those with benign ovarian tumors.