RT Journal Article
SR Electronic
T1 Expression of γ-Synuclein in Bladder Carcinoma: A Possible Marker for Prognosis
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 951
OP 956
VO 36
IS 3
A1 ZHIGANG CHEN
A1 ZHIGANG JI
A1 QINGHAI WANG
A1 BINGBING SHI
A1 CHENGCHAO SHOU
A1 CAIYUN LIU
A1 HUA FAN
A1 HANZHONG LI
A1 KRISTOFFER T. DAVIDSON
A1 MARK R. WAKEFIELD
A1 TYLER W. BALL
A1 YUJIANG FANG
YR 2016
UL http://ar.iiarjournals.org/content/36/3/951.abstract
AB Aim: To investigate if γ-synuclein (SNCG) could be used as a bladder cancer (BC) marker to predict prognosis of BC. Patients and Methods: Medical records of 140 patients with BC (January, 2006 to December, 2009) were retrospectively reviewed. SNCG expression level was examined by immunohistological staining. The patients' survival rate was calculated by the Kaplan–Meier method. Cox proportional regression model was used to identify independent predictors for BC. Results: Overexpression of SNCG was detected in BC tissues and the expression level of SNCG strongly positively correlated with BC recurrence. However, no correlation was found between SNCG level and tumor stage or survival rate. Conclusion: SNCG is a good marker to predict recurrence of BC, but not a reliable marker for staging or prediction of survival rate.