%0 Journal Article %A KENICHI IWASAKI %A YOSHIAKI OSAKA %A SHINGO TACHIBANA %A TAKESHI SUDA %A YOSHIHIRO OTA %A SUMITO HOSHINO %A AKIHIKO TSUCHIDA %T Phase I Study of Docetaxel, Cisplatin, and 5-Fluorouracil Chemoradiotherapy for Local or Metastatic Esophageal Cancer %D 2016 %J Anticancer Research %P 987-994 %V 36 %N 3 %X Background/Aim: Chemoradiotherapy outcomes for unresectable esophageal cancer remain poor. We designed a phase I study of docetaxel, cisplatin (CDDP), and 5-fluorouracil (5-FU) chemoradiotherapy. Patients and Methods: Patients with T4 or M1 esophageal squamous cell carcinoma were enrolled. They received 2 chemotherapy cycles every 4 weeks with these initial doses (Phase I): docetaxel and CDDP (50 mg/m2, days 1 and 29) with continuous 5-FU infusion (600 mg/m2/day, days 1-5 and 29-33). Concurrent radiotherapy (60 Gy) was initiated on day 1. Docetaxel and CDDP plus 5-FU doses were increased to 60 mg/m2 plus 800 mg/m2/day. Results: Out of the 15 patients enrolled, 13 completed the treatment. The MTDs were as follows: docetaxel (60 mg/m2), CDDP (60 mg/m2), and 5-FU (800 mg/m2/day). The overall response rate was 73%, with 27% achieving complete responses. Conclusion: In this phase I trial, docetaxel (60 mg/m2), CDDP (60 mg/m2), and 5-FU (600 mg/m2/day) were considered as the tolerable and active doses. These are the recommended doses for a future phase II trial. %U https://ar.iiarjournals.org/content/anticanres/36/3/987.full.pdf