@article {KRAUSE1403, author = {ROLFDIETER KRAUSE and RAINER STANGE and HEINRICH KAASE and MICHAEL F. HOLICK}, title = {UV Irradiation and Pleiotropic Effects of Vitamin D in Chronic Kidney Disease {\textendash} Benefits on Cardiovascular Comorbidities and Quality of Life}, volume = {36}, number = {3}, pages = {1403--1408}, year = {2016}, publisher = {International Institute of Anticancer Research}, abstract = {Background: Vitamin D3 can be metabolized in the skin to 25(OH)D and 1,25(OH)2D because the skin expresses vitamin D-25-hydroxylase, 25(OH)D-1-alpha-hydroxylase, and the vitamin D receptor. The aim of this review was to discuss the pleiotropic effects after serial suberythemal UVB irradiation with a sun-simulating UV spectrum in end-stage kidney disease patients. Patients and Methods: Fourteen hemodialysis patients, with a mean age of 51 (range 41-57) years, were whole-body UV irradiated over 6 months. Results: Patients demonstrated an increase in their hematocrit and required less erythropoietin. An increase in maximal oxygen uptake and workload capacity was associated with decreased lactic acid production. The patients demonstrated a decreased heart rate and systolic and diastolic blood pressure with an increase in the R-R-interval and the beat-to-beat-differences. Conclusion: Cardiovascular disease is the most important comorbidity. Exposure to simulated sunlight that contains both UVB and UVA reduce cardiovascular risk factors and improve quality of life.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/36/3/1403}, eprint = {https://ar.iiarjournals.org/content/36/3/1403.full.pdf}, journal = {Anticancer Research} }