TY - JOUR T1 - Broad-spectrum Preclinical Antitumor Activity of Eribulin (HalavenĀ®): Combination with Anticancer Agents of Differing Mechanisms JF - Anticancer Research JO - Anticancer Res SP - 3375 LP - 3385 DO - 10.21873/anticanres.12604 VL - 38 IS - 6 AU - MAKOTO ASANO AU - JUNJI MATSUI AU - MURRAY J. TOWLE AU - JIAYI WU AU - SHARON MCGONIGLE AU - MARC HILLAIRET DE BOISFERON AU - TOSHIMITSU UENAKA AU - KENICHI NOMOTO AU - BRUCE A. LITTLEFIELD Y1 - 2018/06/01 UR - http://ar.iiarjournals.org/content/38/6/3375.abstract N2 - Background: Eribulin is used in many countries to treat patients with advanced breast cancer or liposarcoma and exerts in vivo anticancer activity under monotherapy conditions against various human tumor xenograft models. Here, eribulin in combination with mechanistically different anticancer agents was evaluated. Materials and Methods: Eribulin was combined with cytotoxic agents (capecitabine, carboplatin, cisplatin, doxorubicin, gemcitabine) or targeted agents (bevacizumab, BKM-120, E7449, erlotinib, everolimus, lenvatinib, palbociclib) in tumor xenograft models of breast cancer, melanoma, non-small cell lung cancer (NSCLC), and ovarian cancer. Results: Across nearly all models, eribulin with either cytotoxic or targeted agents demonstrated combination activity, defined as the activity demonstrably greater than that of either agent alone. Combination activity was absent only with doxorubicin (MDA-MB-435 model) and with lenvatinib (NCI-H1975 model), both of which responded to the agents as monotherapy. Conclusion: Eribulin has combination activity with multiple agents from different mechanistic classes in several human cancer models, including breast, NSCLC, ovarian, and melanoma. ER -