RT Journal Article SR Electronic T1 Influence of Local Recurrence and Distant Metastasis on Prognosis After Local Excision of Rectal Carcinoma JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 763 OP 768 VO 36 IS 2 A1 THEODOR JUNGINGER A1 URSULA GOENNER A1 MIRJAM HITZLER A1 TONG T. TRINH A1 ANDRE LOLLERT A1 ACHIM HEINTZ A1 DANIEL WOLLSCHLAEGER A1 MARIA BLETTNER YR 2016 UL http://ar.iiarjournals.org/content/36/2/763.abstract AB Background: Influence of local recurrence (LR) on prognosis after a local excision (LE) for rectal cancer is unclear. Patients and Methods: A total of 152 patients were retrospectively assigned to one of three groups: Groups 1 and 2: complete and incomplete resection respectively, for low-risk carcinoma; group 3: high-risk carcinoma. We evaluated LR, distant metastasis (DM), overall survival, and cancer-specific survival (CSS). Results: LR rates were 10.4%, 43% and 29% for groups 1-3, respectively (p=0.002). In all three groups, DM incidence was low in patients without LR, but high in patients with LR (p<0.0001). Prior LR was an important risk factor for DM (hazard ratio: 14.1, 95% confidence interval=4.3-45.8, p<0.0001). DM significantly reduced CSS. Conclusion: There is a strong association between LR and DM independently in the cause of LR. Avoiding LE for high-risk carcinoma and complete LE of low-risk carcinoma are essential to reduce LR and DM.