PT  - JOURNAL ARTICLE
AU  - ONDREJ FIALA
AU  - MILOS PESEK
AU  - JINDRICH FINEK
AU  - MARTIN SVATON
AU  - ONDREJ SOREJS
AU  - ZBYNEK BORTLICEK
AU  - RADEK KUCERA
AU  - ONDREJ TOPOLCAN
TI  - Prognostic Significance of Serum Tumor Markers in Patients with Advanced-stage NSCLC Treated with Pemetrexed-based Chemotherapy
DP  - 2016 Jan 01
TA  - Anticancer Research
PG  - 461--466
VI  - 36
IP  - 1
4099  - http://ar.iiarjournals.org/content/36/1/461.short
4100  - http://ar.iiarjournals.org/content/36/1/461.full
SO  - Anticancer Res2016 Jan 01; 36
AB  - Background: Tumor biomarkers represent effective tools for diagnostics and follow-up monitoring of patients with non-small cell lung cancer (NSCLC). We focused on evaluating the predictive and prognostic role of the seven following tumor biomarkers: carcinoembryonic antigen (CEA), cytokeratin-19 fragment (CYFRA 21-1), fragments of cytokeratin 8, 18 and 19 (MonoTotal), neuron-specific enolase (NSE), chromogranin A, thymidine kinase (TK) and squamous cell carcinoma antigen (SCCA) in patients with advanced-stage NSCLC treated with pemetrexed-based chemotherapy. Patients and Methods: In total, 114 patients with advanced-stage (IIIB or IV) non-squamous NSCLC treated with pemetrexed-based chemotherapy (monotherapy or combination with a platinum derivative) were included. Comparison of progression-free (PFS) and overall survival (OS) according to the level of assessed tumor markers was performed using the log-rank test. Results: We recorded significantly shorter OS for patients with high pretreatment levels of CYFRA 21-1 (10.3 vs. 23.4 months; p<0.001), NSE (1.6 vs. 13.5 months; p=0.003) and TK (11.3 vs. 23.4 months; p=0.003). Conclusion: CYFRA 21-1, NSE and TK are feasible biomarkers for estimation of a patient's overall prognosis, however, none of the measured serum tumor markers were able to predict the efficacy of pemetrexed-based chemotherapy.