RT Journal Article SR Electronic T1 Malignant Ovarian Germ Cell Tumors in Postmenopausal Patients: The Royal Marsden Experience and Literature Review JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 6713 OP 6722 VO 35 IS 12 A1 STERGIOS BOUSSIOS A1 AYOMA ATTYGALLE A1 STEVE HAZELL A1 MICHELE MOSCHETTA A1 JENNIFER MCLACHLAN A1 ALICIA OKINES A1 SUSANA BANERJEE YR 2015 UL http://ar.iiarjournals.org/content/35/12/6713.abstract AB Background: Ovarian germ cell tumors (OGCT) account for 2-5% of ovarian malignancies, with an annual incidence of 1:100,000, and typically occur in young women and adolescents. The yolk sac tumor (YST) is the second most common subtype of OGCTs and has an aggressive phenotype. Their rarity in postmenopausal women has the potential to cause initial diagnostic uncertainty and lead to delayed or sub-optimal treatment. In this article, we report two cases. The first case is a 67-year-old woman with a pure YST and the second refers to a 59-year-old patient with YST with neuroendocrine differentiation. We also review and summarise the current literature. Discussion: YSTs in older women, either in association with ovarian epithelial tumors or without an identifiable epithelial precursor, are a challenging clinical situation. The disease is aggressive and the outcome remains poor. Thirty-seven cases, including the two reported in this article, have been described in the literature to date. 12/ 37 described patients with malignant OGCTs died within 8 months of diagnosis. Conclusion: Ovarian cancer with a YST component in postmenopausal women has an aggressive behaviour and adjuvant platinum-based chemotherapy should be considered.