RT Journal Article
SR Electronic
T1 Predicting the Risk of New Cerebral Lesions After Stereotactic Radiosurgery (SRS) for Brain Metastases from Breast Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 6793
OP 6797
VO 35
IS 12
A1 LIESA DZIGGEL
A1 MARKUS DAHLKE
A1 STEFAN JANSSEN
A1 DAGMAR HORNUNG
A1 OLIVER BLANCK
A1 MAI TRONG KHOA
A1 STEVEN E. SCHILD
A1 DIRK RADES
YR 2015
UL http://ar.iiarjournals.org/content/35/12/6793.abstract
AB Aim: To generate a tool that estimates the probability of developing new cerebral metastases after stereotactic radiosurgery (SRS) in breast cancer patients. Patients and Methods: SRS dose plus seven characteristics (age, performance score, number of cerebral metastases, maximum diameter of all metastases, location of metastases, extra-cerebral spread and time from breast cancer diagnosis until SRS) were analyzed regarding their ability to predict the probability of new cerebral metastases development following SRS. For those characteristics deemed significant, points of 0 (higher risk of new lesions) or 1 (lower risk) were given. Scores were generated by adding the points of significant characteristics. Results: Performance score (p=0.013) and maximum diameter of all metastases (p=0.022) were associated with development of subsequent brain metastases. Two groups were created, 0-1 and 2 points. Freedom from new cerebral metastases rates were 27% and 92%, respectively, at 15 months (p=0.003). Conclusion: This tool helps select breast cancer with few cerebral metastases receiving SRS who may benefit from additional whole-brain irradiation.