PT - JOURNAL ARTICLE AU - LAURA A. SORDILLO AU - PETER P. SORDILLO AU - LAWRENCE HELSON TI - Curcumin for the Treatment of Glioblastoma DP - 2015 Dec 01 TA - Anticancer Research PG - 6373--6378 VI - 35 IP - 12 4099 - http://ar.iiarjournals.org/content/35/12/6373.short 4100 - http://ar.iiarjournals.org/content/35/12/6373.full SO - Anticancer Res2015 Dec 01; 35 AB - Glioblastoma multiforme is a highly aggressive primary cancer of the brain associated with a poor prognosis. Modest increases in survival can sometimes be achieved with the use of temozolomide and radiation therapy after surgery, but second-line therapy after recurrence has a limited efficacy. Curcumin has demonstrated promising results against this form of cancer in experimental models. The reported activity of curcumin against cancer stem cells, a major cause of glioblastoma resistance to therapy, and its ability to augment the apoptotic effects of ceramides, suggest it would have a synergistic effect with cytotoxic chemotherapy agents currently used in second-line therapy, such as lomustine.