PT - JOURNAL ARTICLE AU - MEGAN G. LOCKYER AU - DANIEL G. ROSEN TI - Extraskeletal Myxoid Chondrosarcoma Presenting as a Plantar Fibroma: Case Report and Review of the Literature DP - 2015 Nov 01 TA - Anticancer Research PG - 6171--6174 VI - 35 IP - 11 4099 - http://ar.iiarjournals.org/content/35/11/6171.short 4100 - http://ar.iiarjournals.org/content/35/11/6171.full SO - Anticancer Res2015 Nov 01; 35 AB - Background: Extraskeletal myxoid chondrosarcoma is a rare tumor with an indolent course, high propensity for local recurrence, metastases, and propensity for the proximal extremities of middle-aged males. Case Report: We present the case of a 44-year-old man with an extraskeletal myxoid chondrosarcoma in the plantar fascia of the medial arch initially thought to be a plantar fibroma. Magnetic resonance imaging of the lesion demonstrated a lobulated subcutaneous mass plantar to the tarsal bones and inseparable from the fascia. Microscopic examination revealed a lobulated lesion composed of cords and nests of round to spindled malignant cells in a blue-gray myxoid matrix surrounded by fibrous septae. The malignant cells displayed variable positivity for S-100. Conclusion: Plantar extraskeletal myxoid chondrosarcoma is a rare occurrence. It should always be considered in the differential diagnosis of masses arising in the plantar fascia of the foot.