RT Journal Article
SR Electronic
T1 Fluctuation in Plasma 5-Fluorouracil Concentration During Continuous 5-Fluorouracil Infusion for Colorectal Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 6193
OP 6199
VO 35
IS 11
A1 HIDEO MATSUMOTO
A1 HIDEO OKUMURA
A1 HARUAKI MURAKAMI
A1 HISAKO KUBOTA
A1 MASAHARU HIGASHIDA
A1 ATSUSHI TSURUTA
A1 KAORU TOHYAMA
A1 TOSHIHIRO HIRAI
YR 2015
UL http://ar.iiarjournals.org/content/35/11/6193.abstract
AB Background/Aim: It is generally believed that the plasma concentration of 5-fluorouracil (5-FU) is constant when 5-FU is continually administered for chemotherapy. The aim of the present study was to verify whether this is true. Patients and Methods: Nine patients with colorectal cancer were enrolled in this study. All patients received chemotherapy; four patients received FOLFIRI (leucovorin, 5-fluorouracil, irinotecan) and five received FOLFOX (leucovorin, 5-fluorouracil, oxaliplatin). 5-FU was administered continuously (2400 mg/m2) for 46 h. Serum was collected at 12 points after the start of administration. The concentration of 5-FU was evaluated using a new immunoassay method and gas chromatography–mass spectrometric (GC/MS) method. Results: The concentrations of 5-FU fluctuated dramatically over time, with greater than 3-fold changes in each individual, and the pattern was not constant. Conclusion: Because the serum concentration of 5-FU fluctuates and displays various patterns, the dosage should not be based on body surface area. A new individualized method for determining the 5-FU dosage should be developed.