RT Journal Article
SR Electronic
T1 Induction of Acute Myeloid Leukemia with Idarubicin, Cytarabine and Cladribine
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 6287
OP 6290
VO 35
IS 11
A1 ERIC WIEDOWER
A1 OMER JAMY
A1 MICHAEL G. MARTIN
YR 2015
UL http://ar.iiarjournals.org/content/35/11/6287.abstract
AB Background: Daunorubicin and cytarabine has been the standard-of-care for induction therapy for acute myeloid leukemia (AML). Adding cladribine to daunorubicin (60 mg/m2) and cytarabine has increased complete remission (CR) rates and median overall survival (OS). However, the efficacy of adding cladribine to 7+3 with other anthracyclines is unknown. Patients and Methods: We retrospectively evaluated patients with AML receiving induction with idarubicin, cytarabine and cladribine (ICC) between 1/1/2010 and 06/30/2015 at the Methodist University Hospital in Memphis, Tennessee. Institutional Review Board approval was obtained for the study. Patient, disease characteristics and outcomes were analyzed with GraphPad Prism, Microsoft Excel and SPSSv19.0 software. Results: Twenty-four patients induced with ICC for AML were identified. Thirteen (54.2%) had at least one high-risk feature. Hypoplastic marrow was achieved in all by day 14; 19 (79.2%) achieved CR. Thirty-day mortality was 8.3%; 33-month OS and disease-free survival were 56% and 36%, respectively. Conclusion: Induction of AML with ICC was associated with a high CR rate and OS in our high-risk population.