RT Journal Article SR Electronic T1 Long-term Survival with Ipilimumab: Experience from a National Expanded Access Program for Patients with Melanoma JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 6303 OP 6310 VO 35 IS 11 A1 IVANA KRAJSOVÁ A1 PETR ARENBERGER A1 RADEK LAKOMÝ A1 EUGEN KUBALA A1 IVANA BŘEZINOVÁ A1 ALEXANDR POPRACH A1 MAREK ŠŤASTNÝ A1 JAN MUŽÍK A1 BOHUSLAV MELICHAR YR 2015 UL http://ar.iiarjournals.org/content/35/11/6303.abstract AB Aim: Evaluation of efficacy and safety of ipilimumab in patients with advanced, refractory melanoma enrolled into a national ipilimumab Expanded Access Program. Patients and Methods: Adult patients with advanced/metastatic refractory melanoma were eligible for study inclusion. Ipilimumab was administered up to a total of four doses. Results: One hundred and ninety-six patients were analyzed. Full ipilimumab induction was administered to 66.8% of patients. Median overall survival (OS) in the entire cohort was 7.5 months. Median OS for patients after four doses of ipilimumab was significantly longer than for patients with fewer doses (12.3 months vs. 2.0 months respectively; p<0.001). Median OS for patients with objective tumor response was 42.3 months. Normal baseline serum lactate dehydrogenase (LDH) and C-reactive protein (CRP) levels, and the number of affected organs correlated with improved OS. Conclusion: The number of affected organs and combination of baseline LDH and CRP levels could potentially serve as predictors for both treatment response and OS.