RT Journal Article SR Electronic T1 Electrochemotherapy – Evidence for Cell-type Selectivity In Vitro JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 5813 OP 5820 VO 35 IS 11 A1 FREDRIK LANDSTRÖM A1 MIKAEL IVARSSON A1 ANITA KOSKELA VON SYDOW A1 ANDERS MAGNUSON A1 MATHIAS VON BECKERATH A1 CLAES MÖLLER YR 2015 UL http://ar.iiarjournals.org/content/35/11/5813.abstract AB Aim: Electrochemotherapy (ECT) is a new cancer treatment modality that uses electroporation to potentiate chemotherapeutic agents, especially bleomycin. ECT causes both a direct toxic effect and an anti-vascular effect. The aim of the present study was to investigate a possible selective effect of ECT on the survival of fibroblasts, endothelial cells (HUVEC) and two squamous cell carcinoma cell lines (CAL-27 and SCC-4). Materials and Methods: Cells were electroporated using two bleomycin concentrations. The survival rate was assessed 1, 2, 3 and 4 days after treatment, by two different assays. Results: The survival rate of the fibroblasts was statistically significantly higher than the other cell lines at day 4. The HUVEC survival rate was statistically significantly lower than the other cell types at day 1 after electroporation-alone. Conclusion: A selective survival effect after ECT was observed in vitro, supporting the anti-vascular effect seen in vivo.