PT  - JOURNAL ARTICLE
AU  - RADES, DIRK
AU  - CONDE-MORENO, ANTONIO J.
AU  - CACICEDO, JON
AU  - SEGEDIN, BARBARA
AU  - VENINGA, THEO
AU  - SCHILD, STEVEN E.
TI  - Metastatic Spinal Cord Compression: A Survival Score Particularly Developed for Elderly Prostate Cancer Patients
DP  - 2015 Nov 01
TA  - Anticancer Research
PG  - 6189--6192
VI  - 35
IP  - 11
4099  - http://ar.iiarjournals.org/content/35/11/6189.short
4100  - http://ar.iiarjournals.org/content/35/11/6189.full
SO  - Anticancer Res2015 Nov 01; 35
AB  - Aim: Metastatic spinal cord compression (MSCC) is an oncological emergency. Many elderly patients cannot tolerate intensive treatment and need individual approaches accounting for a patient's remaining lifetime. The goal of the present study was to develop a survival score for elderly prostate cancer patients with MSCC. Patients and Methods: Nine characteristics were analyzed in 243 patients: age, performance status, interval from prostate cancer diagnosis until MSCC, affected vertebrae, ambulatory status, further bone lesions, visceral metastases, time developing motor deficits, fractionation schedule. Results: Pre-radiotherapy ambulatory status (p<0.001), visceral metastases (p<0.001) and time developing motor deficits (p<0.001) were significant for survival on Cox regression analysis and included in the survival score. Four groups were defined: 9-12, 13-16, 17-19 and 21-23 points. Six-month survival rates were 7%, 28%, 71% and 95%, respectively (p<0.001). Conclusion: The present study identified four groups with different survival probabilities that require treatment strategies with different priorities ranging from symptom control to prolongation of life.