RT Journal Article
SR Electronic
T1 A New Predictive Tool for Optimization of the Treatment of Brain Metastases from Colorectal Cancer After Stereotactic Radiosurgery
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5515
OP 5518
VO 35
IS 10
A1 RADES, DIRK
A1 DAHLKE, MARKUS
A1 GEBAUER, NIKLAS
A1 BARTSCHT, TOBIAS
A1 HORNUNG, DAGMAR
A1 TRANG, NGO THUY
A1 PHUONG, PHAM CAM
A1 KHOA, MAI TRONG
A1 GLIEMROTH, JAN
YR 2015
UL http://ar.iiarjournals.org/content/35/10/5515.abstract
AB Aim: To develop a predictive tool for survival after stereotactic radiosurgery of brain metastases from colorectal cancer. Patients and Methods: Out of nine factors analyzed for survival, those showing significance (p<0.05) or a trend (p≤0.06) were included. For each factor, 0 (worse survival) or 1 (better survival) point was assigned. Total scores represented the sum of the factor scores. Results: Performance status (p=0.010) and interval from diagnosis of colorectal cancer until radiosurgery (p=0.026) achieved significance, extracranial metastases showed a trend (p=0.06). These factors were included in the tool. Total scores were 0-3 points. Six-month survival rates were 17% for patients with 0, 25% for those with 1, 67% for those with 2 and 100% for those with 3 points; 12-month rates were 0%, 0%, 33% and 67%, respectively. Two groups were created: 0-1 and 2-3 points. Six- and 12-month survival rates were 20% vs. 78% and 0% vs. 44% (p=0.002), respectively. Conclusion: This tool helps optimize the treatment of patients after stereotactic radiosurgery for brain metastases from colorectal cancer.