TY - JOUR T1 - Chronic Lymphocytic Leukemia: Current Concepts JF - Anticancer Research JO - Anticancer Res SP - 5149 LP - 5165 VL - 35 IS - 10 AU - EUN-MI YU AU - ADAM KITTAI AU - IMAD A. TABBARA Y1 - 2015/10/01 UR - http://ar.iiarjournals.org/content/35/10/5149.abstract N2 - Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in adults, and while in early, asymptomatic stages treatment is not indicated, the threat to the quality of life and increased mortality of patients posed by more advanced-stage disease necessitate therapeutic intervention. Guidelines of when and how to treat are not well-established because CLL is a disease of the elderly and it is important to balance preservation of functional status and control of the disease. Advances in molecular and genetic profiling has led to the ability to identify sub-groups of patients with CLL whose disease may respond to selected therapy. This review discusses current standard therapies in the major sub-groups of CLL based on age and functional status, in both the front-line and relapsed/refractory settings. It also provides a concise review of novel agents that have shown considerable efficacy in CLL. ER -