RT Journal Article
SR Electronic
T1 Human Mesenchymal Stem Cells Protect Dorsal Root Ganglia from the Neurotoxic Effect of Cisplatin
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5383
OP 5389
VO 35
IS 10
A1 ARIANNA SCUTERI
A1 MADDALENA RAVASI
A1 MARIANNA MONFRINI
A1 AZZURRA MILANO
A1 GIOVANNA D'AMICO
A1 MARIAROSARIA MILOSO
A1 GIOVANNI TREDICI
YR 2015
UL http://ar.iiarjournals.org/content/35/10/5383.abstract
AB Background/Aim: Peripheral neurotoxicity is a dose-limiting factor of many chemotherapeutic agents, including cisplatin. Mesenchymal stem cells are promising for the treatment of several neurological disorders, and our aim was to verify the neuroprotective potential of human mesenchymal stem cells (hMSCs) on dorsal root ganglia (DRG) exposed to cisplatin. Materials and Methods: DRG were exposed to different cisplatin concentrations and then co-cultured with hMSCs or with hMSC-conditioned medium. Results: hMSCs showed a neuroprotective effect on cisplatin-induced death of DRG, mediated by direct contact. Moreover, DRG exhibited an MSC-dependent promotion of neurite outgrowth, in particular at early time points. For this effect, the expression of Neurite Outgrowth Inhibitor (NOGO) and Myelin Associated Glycoprotein (MAG) by hMSCs was pivotal. Conclusion: hMSCs are a promising tool for reducing the neurotoxic effect of cisplatin.