PT  - JOURNAL ARTICLE
AU  - ARIANNA SCUTERI
AU  - MADDALENA RAVASI
AU  - MARIANNA MONFRINI
AU  - AZZURRA MILANO
AU  - GIOVANNA D'AMICO
AU  - MARIAROSARIA MILOSO
AU  - GIOVANNI TREDICI
TI  - Human Mesenchymal Stem Cells Protect Dorsal Root Ganglia from the Neurotoxic Effect of Cisplatin
DP  - 2015 Oct 01
TA  - Anticancer Research
PG  - 5383--5389
VI  - 35
IP  - 10
4099  - http://ar.iiarjournals.org/content/35/10/5383.short
4100  - http://ar.iiarjournals.org/content/35/10/5383.full
SO  - Anticancer Res2015 Oct 01; 35
AB  - Background/Aim: Peripheral neurotoxicity is a dose-limiting factor of many chemotherapeutic agents, including cisplatin. Mesenchymal stem cells are promising for the treatment of several neurological disorders, and our aim was to verify the neuroprotective potential of human mesenchymal stem cells (hMSCs) on dorsal root ganglia (DRG) exposed to cisplatin. Materials and Methods: DRG were exposed to different cisplatin concentrations and then co-cultured with hMSCs or with hMSC-conditioned medium. Results: hMSCs showed a neuroprotective effect on cisplatin-induced death of DRG, mediated by direct contact. Moreover, DRG exhibited an MSC-dependent promotion of neurite outgrowth, in particular at early time points. For this effect, the expression of Neurite Outgrowth Inhibitor (NOGO) and Myelin Associated Glycoprotein (MAG) by hMSCs was pivotal. Conclusion: hMSCs are a promising tool for reducing the neurotoxic effect of cisplatin.