<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">DAVIES, RHIAN SIÂN</style></author><author><style face="normal" font="default" size="100%">SMITH, CHRISTIAN</style></author><author><style face="normal" font="default" size="100%">BUTTON, MICHAEL ROBERT</style></author><author><style face="normal" font="default" size="100%">TANGUAY, JACOB</style></author><author><style face="normal" font="default" size="100%">BARBER, JIM</style></author><author><style face="normal" font="default" size="100%">PALANIAPPAN, NACHIAPPAN</style></author><author><style face="normal" font="default" size="100%">STAFFURTH, JOHN</style></author><author><style face="normal" font="default" size="100%">LESTER, JASON FRANCIS</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">What Predicts Minimal Response to Abiraterone in Metastatic Castrate-resistant Prostate Cancer?</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2015-10-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">5615-5621</style></pages><volume><style face="normal" font="default" size="100%">35</style></volume><issue><style face="normal" font="default" size="100%">10</style></issue><abstract><style  face="normal" font="default" size="100%">Background: Several treatments have been shown to prolong survival in metastatic castrate-resistant prostate cancer (mCRPC); the optimum sequencing of these is not established. We investigated methods of identifying patients with mCRPC unlikely to respond to abiraterone. Patients and Methods: A retrospective analysis was carried-out in 47 consecutive patients with mCRPC treated sequentially with androgen deprivation (LHRHa), bicalutamide, docetaxel then abiraterone. Results: The median progression-free survival in patients treated with abiraterone was shorter in those with ≤18 months' response to LHRHa (118 vs. 279 days; p=0.018), bicalutamide non-responders (91 vs. 196 days; p=0.003) and patients with ≤6 months' response to docetaxel (102 vs. 294 days; p&lt;0.001). The median overall survival was also shorter (348 vs. 815 days, p=0.016; 413 vs. 752 days, p=0.009; and 325 vs. 727 days, p&lt;0.04, respectively). Conclusion: A response of ≤18 months' to LHRHa, non-response to bicalutamide and ≤6 months' response to docetaxel predicted poor response to abiraterone.</style></abstract></record></records></xml>