RT Journal Article
SR Electronic
T1 Defining the Optimal Dose of Stereotactic Radiosurgery for Treating Cerebral Metastases in Elderly Patients
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5701
OP 5704
VO 35
IS 10
A1 RADES, DIRK
A1 DAHLKE, MARKUS
A1 DZIGGEL, LIESA
A1 JANSSEN, STEFAN
A1 BAJROVIC, AMIRA
A1 TRANG, NGO THUY
A1 KHOA, MAI TRONG
A1 SCHILD, STEVEN E.
YR 2015
UL http://ar.iiarjournals.org/content/35/10/5701.abstract
AB Background/Aim: In oncology, elderly people are a separate group of patients requiring special consideration. This applies to the treatment of cerebral metastases as well. The present study focused on elderly patients receiving stereotactic radiosurgery (SRS) for few cerebral lesions. Patients and Methods: In 95 patients aged ≥65 years, two SRS doses, 16-18 Gy (n=44) and 20 Gy (n=51), were compared regarding outcomes of SRS. Results: The overall intracerebral control rates at 12 months were 30% after 16-18 Gy and 45% after 20 Gy (p=0.53). Twelve-month rates of freedom from new intracerebral lesions were 41% and 52%, respectively (p=0.63). Twelve-month local control rates of the irradiated lesions were 55% and 81%, respectively (p=0.069). Overall survival rates at 12 months were 29% and 31%, respectively (p=0.67). Conclusion: SRS with 16-18 Gy was not significantly inferior to SRS with 20 Gy in elderly patients with few cerebral metastases.