PT - JOURNAL ARTICLE AU - JAUME TRAPÉ AU - GABRIEL GURT AU - JOSEFINA FRANQUESA AU - JESÚS MONTESINOS AU - ANNA ARNAU AU - MARIA SALA AU - FRANCESC SANT AU - ESTHER CASADO AU - JOSEP MARIA ORDEIG AU - CARMEN BERGOS AU - FRANCESC VIDA AU - PAU SORT AU - ÁLVARO ISAVA AU - MONTSERRAT GONZÁLEZ AU - RAFAEL MOLINA TI - Diagnostic Accuracy of Tumor Markers CYFRA21-1 and CA125 in the Differential Diagnosis of Ascites DP - 2015 Oct 01 TA - Anticancer Research PG - 5655--5660 VI - 35 IP - 10 4099 - http://ar.iiarjournals.org/content/35/10/5655.short 4100 - http://ar.iiarjournals.org/content/35/10/5655.full SO - Anticancer Res2015 Oct 01; 35 AB - Background: The usefulness of tumor markers in the differential diagnosis of cancer in patients with ascites remains a matter of controversy. Few studies have reported the measurement of cancer antigen 125 (CA125) and cytokeratin 19 soluble fragments (CYFRA21-1) in ascitic fluid. The aim of the present study was to evaluate the diagnostic accuracy of these tumor markers in the detection of malignant ascites. Materials and Methods: We analyzed CA125 and CYFRA21-1 from 143 consecutive undiagnosed patients with ascitis. Results: Use of CA125 gave a sensitivity of 39.7% and a specificity of 98.8%, and CYFRA21-1 a sensitivity of 50.0% and a specificity of 97.6% in differential diagnosis of malignant ascites. For combined use of CA125 plus CYFRA21-1, sensitivity was 65.5% and specificity 96.5%. In patients with negative cytology, these two tumor markers had a sensitivity of 50% and a specificity of 96.5%. Conclusion: The determination of tumor markers in ascitic fluid could be useful for the diagnostic assessment of patients with ascites.