RT Journal Article
SR Electronic
T1 Complexity of Response Evaluation During Primary Systemic Therapy of Breast Cancer: Scoring Systems and Beyond–Preliminary Results
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5063
OP 5072
VO 35
IS 9
A1 TÍMEA TŐKÉS
A1 GYÖNGYVÉR SZENTMÁRTONI
A1 LÁSZLÓ TORGYÍK
A1 KRISZTIÁN SOMLAI
A1 JANINA KULKA
A1 ZSOLT LENGYEL
A1 TAMÁS GYÖRKE
A1 MAGDOLNA DANK
YR 2015
UL http://ar.iiarjournals.org/content/35/9/5063.abstract
AB Background: Precise and standardized response evaluation enables clinicians to tailor primary systemic therapy (PST). Patients and Methods: Breast cancer patients underwent 18F-fluoro-deoxy-glucose positron emission tomography and computerized tomography (FDG-PET/CT) before and after PST. Response was assessed by maximal Standardized Uptake Value (SUVmax); morphological changes and Ki-67 labeling index (LI). In parallel response assessment was performed by European Organization for Research and Treatment of Cancer (EORTC); PET Response Criteria in Solid Tumors (PERCIST); World Health Organization (WHO); Response Evaluation Criteria in Solid Tumors (RECIST); Chevallier and Sataloff classifications, and by a novel Ki-67 score. Accuracy of different scoring systems was evaluated. Results: In the 42 enrolled patients, SUVmax, size, and Ki-67 LI decreased significantly on PST. Significant differences between patients with versus those without pathological complete response were observed for pre-treatment Ki-67 LI and SUVmax and for post-treatment Ki-67 LI, SUVmax and size. Change in Ki-67 LI was the best predictor of pathological complete response. Correlation patterns of the directly measured metabolic, morphological, and proliferation responses differed from those determined by scoring methods. Conclusion: During PST, FDG-PET/CT enables for robust assessment of treatment efficacy, but more reliable scoring systems are still needed for more precise response evaluation.