RT Journal Article SR Electronic T1 Results of Primary Cytoreductive Surgery in Advanced-stage Epithelial Ovarian Cancer: A Single-center Experience JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 4099 OP 4104 VO 35 IS 7 A1 NICOLAE BACALBASA A1 SIMONA DIMA A1 IRINA BALESCU A1 LEONARD DAVID A1 VLADISLAV BRASOVEANU A1 IRINEL POPESCU YR 2015 UL http://ar.iiarjournals.org/content/35/7/4099.abstract AB Aim: To determine the impact of maximal cytoreductive surgery on overall survival in advanced epithelial ovarian cancer. Patients and Methods: We retrospectively reviewed medical data of patients submitted to primary cytoreductive surgery for advanced epithelial cancer in the Fundeni Clinical Hospital between 1 January 2002 and 1 April 2014. Results: A total of 338 patients were eligible for the study. Complete cytoreduction was achieved in 242 patients and was associated with a significantly improved survival (p<0.001), when compared to patients in whom incomplete debulking surgery was performed. Other prognostic factors associated with an improved survival were stage by the International Federation of Gynecology and Obstetrics and the preoperative biological status of the patient. Conclusion: A more extensive surgical approach is perfectly justified and associated with improved survival in patients with advanced-stage epithelial ovarian cancer. However, patient selection should be performed carefully because the general preoperative status can significantly impact survival.