TY - JOUR T1 - Results of Primary Cytoreductive Surgery in Advanced-stage Epithelial Ovarian Cancer: A Single-center Experience JF - Anticancer Research JO - Anticancer Res SP - 4099 LP - 4104 VL - 35 IS - 7 AU - NICOLAE BACALBASA AU - SIMONA DIMA AU - IRINA BALESCU AU - LEONARD DAVID AU - VLADISLAV BRASOVEANU AU - IRINEL POPESCU Y1 - 2015/07/01 UR - http://ar.iiarjournals.org/content/35/7/4099.abstract N2 - Aim: To determine the impact of maximal cytoreductive surgery on overall survival in advanced epithelial ovarian cancer. Patients and Methods: We retrospectively reviewed medical data of patients submitted to primary cytoreductive surgery for advanced epithelial cancer in the Fundeni Clinical Hospital between 1 January 2002 and 1 April 2014. Results: A total of 338 patients were eligible for the study. Complete cytoreduction was achieved in 242 patients and was associated with a significantly improved survival (p<0.001), when compared to patients in whom incomplete debulking surgery was performed. Other prognostic factors associated with an improved survival were stage by the International Federation of Gynecology and Obstetrics and the preoperative biological status of the patient. Conclusion: A more extensive surgical approach is perfectly justified and associated with improved survival in patients with advanced-stage epithelial ovarian cancer. However, patient selection should be performed carefully because the general preoperative status can significantly impact survival. ER -