RT Journal Article
SR Electronic
T1 Altered Expression of Yes-associated Protein and β-Catenin in Non-neoplastic and Neoplastic Gastric Surface Epithelia
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3925
OP 3931
VO 35
IS 7
A1 SEOK-HYUNG KIM
A1 OK-JUN LEE
A1 JU-LEE KWON
A1 JIN MAN KIM
A1 HAE-JOUNG SUL
A1 KYU SANG SONG
A1 KYUNG-HEE KIM
YR 2015
UL http://ar.iiarjournals.org/content/35/7/3925.abstract
AB Aim: To investigate whether differential expression of Yes-associated protein (YAP) and β-catenin is important in gastric carcinogenesis. Materials and Methods: A total of 284 paraffin-embedded samples collected from 232 patients with gastric adenocarcinoma were used to evaluate YAP and β-catenin expression by immunohistochemistry, and the experimental findings were compared against those for gastric adenocarcinoma cell lines. Results: Nuclear YAP expression gradually increased from non-neoplastic epithelia to tubular or papillary adenocarcinomas (TPADs) and decreased in signet-ring cell carcinoma (SRCC). Cytoplasmic β-catenin expression increased from non-neoplastic epithelia to high-grade dysplasia and was decreased in TPAD and SRCC. YAP-overexpressing cell lines exhibited marked tumor cell invasion, whereas YAP-depleted cells showed reduced invasion. Conclusion: Nuclear YAP and cytoplasmic β-catenin play important roles in carcinogenesis, and the differential patterns YAP and β-catenin expression between TPAD and SRCC imply the existence of different carcinogenic pathways in these conditions.