TY - JOUR T1 - Contribution of Genotype of DNA Double-strand Break Repair Gene <em>XRCC3</em>, Gender, and Smoking Behavior to Lung Cancer Risk in Taiwan JF - Anticancer Research JO - Anticancer Res SP - 3893 LP - 3899 VL - 35 IS - 7 AU - HUNG-JEN CHEN AU - WEN-SHIN CHANG AU - TE-CHUN HSIA AU - CHIA-EN MIAO AU - WEI-CHUN CHEN AU - SHINN-JYE LIANG AU - AN-CHYI CHEN AU - JAN-GOWTH CHANG AU - CHIA-WEN TSAI AU - CHIN-MU HSU AU - CHANG-HAI TSAI AU - DA-TIAN BAU Y1 - 2015/07/01 UR - http://ar.iiarjournals.org/content/35/7/3893.abstract N2 - Aim: The present study evaluated the contribution of genotype of X-ray repair cross-complementing group 3 (XRCC3), age, gender, and smoking to lung cancer risk in Taiwan. Materials and Methods: A total of 358 patients with lung cancer and 716 controls were investigated for their XRCC3 rs1799794, rs45603942, rs861530, rs3212057, rs1799796, rs861539, rs28903081 genotype, epidemiological and clinical data for association and gene-Iifestyle interactions. Results: The results showed that CT and TT genotypes of XRCC3 rs861539 were associated with increased lung cancer risk (odds ratio=1.81, 95% confidence interval=1.18-2.78; odds ratio=3.43, 95% confidence interval=1.12-10.60, respectively). This polymorphism also influenced lung cancer susceptibility in males and smokers (p=0.0017 and 0.0045, respectively). Conclusion: The T allele of XRCC3 rs861539 contributes to increased risk of lung cancer in Taiwanese, particularly those who are male and smokers. ER -