%0 Journal Article %A HUNG-JEN CHEN %A WEN-SHIN CHANG %A TE-CHUN HSIA %A CHIA-EN MIAO %A WEI-CHUN CHEN %A SHINN-JYE LIANG %A AN-CHYI CHEN %A JAN-GOWTH CHANG %A CHIA-WEN TSAI %A CHIN-MU HSU %A CHANG-HAI TSAI %A DA-TIAN BAU %T Contribution of Genotype of DNA Double-strand Break Repair Gene XRCC3, Gender, and Smoking Behavior to Lung Cancer Risk in Taiwan %D 2015 %J Anticancer Research %P 3893-3899 %V 35 %N 7 %X Aim: The present study evaluated the contribution of genotype of X-ray repair cross-complementing group 3 (XRCC3), age, gender, and smoking to lung cancer risk in Taiwan. Materials and Methods: A total of 358 patients with lung cancer and 716 controls were investigated for their XRCC3 rs1799794, rs45603942, rs861530, rs3212057, rs1799796, rs861539, rs28903081 genotype, epidemiological and clinical data for association and gene-Iifestyle interactions. Results: The results showed that CT and TT genotypes of XRCC3 rs861539 were associated with increased lung cancer risk (odds ratio=1.81, 95% confidence interval=1.18-2.78; odds ratio=3.43, 95% confidence interval=1.12-10.60, respectively). This polymorphism also influenced lung cancer susceptibility in males and smokers (p=0.0017 and 0.0045, respectively). Conclusion: The T allele of XRCC3 rs861539 contributes to increased risk of lung cancer in Taiwanese, particularly those who are male and smokers. %U https://ar.iiarjournals.org/content/anticanres/35/7/3893.full.pdf