PT  - JOURNAL ARTICLE
AU  - SANTOS, MARTA
AU  - CORREIA-GOMES, CARLA
AU  - MARCOS, RICARDO
AU  - SANTOS, ANDREIA
AU  - DE MATOS, AUGUSTO
AU  - LOPES, CARLOS
AU  - DIAS-PEREIRA, PATRÍCIA
TI  - Value of the Nottingham Histological Grading Parameters and Nottingham Prognostic Index in Canine Mammary Carcinoma
DP  - 2015 Jul 01
TA  - Anticancer Research
PG  - 4219--4227
VI  - 35
IP  - 7
4099  - http://ar.iiarjournals.org/content/35/7/4219.short
4100  - http://ar.iiarjournals.org/content/35/7/4219.full
SO  - Anticancer Res2015 Jul 01; 35
AB  - Background/Aim: In the past decade, the human Nottingham histological grade (NHG) has been applied to canine mammary carcinomas (CMC). The Nottingham Prognostic Index (NPI) enables identification of more aggressive human breast cancer. The prognostic value of grading parameters and NPI has never been detailed in CMC. The aim of the present study was to assess the prognostic value of NHG, its parameters and NPI. Materials and Methods: Univariable and multivariable analyses were used to assess the prognostic value of NHG, its parameters and NPI in a cohort of 59 dogs with CMC. Results: Short disease-free interval and overall survival were associated with higher NHG, particularly of grade III. Only high nuclear pleomorphism score was significantly associated with poor survival. NPI exhibited a strong predictive value for disease progression. Conclusion: NHG, nuclear pleomorphism and NPI have prognostic value in CMC. Nuclear pleomorphism is an independent prognostic factor. Evaluation of nuclear pleomorphism should be included in routine pathology reports.