TY - JOUR T1 - Contemporary Incidence and Mortality Rates of Neuroendocrine Prostate Cancer JF - Anticancer Research JO - Anticancer Res SP - 4145 LP - 4150 VL - 35 IS - 7 AU - SHAHEEN ALANEE AU - AARON MOORE AU - MAX NUTT AU - BRADLEY HOLLAND AU - DANUTA DYNDA AU - AHMED EL-ZAWAHRY AU - KEVIN T. McVARY Y1 - 2015/07/01 UR - http://ar.iiarjournals.org/content/35/7/4145.abstract N2 - Aim: The purpose of the study was to provide an update ever the incidence and mortality for neuroendocrine prostate cancer (NEPC) in the United States. Patients and Methods: Using a large national database, we examined changes in age-adjusted incidence (AAIR), mortality rates (MR) and 5-year cancer-specific survival (CSS) for 378 patients diagnosed with NEPC between 1992 and 2011. Analysis was performed for all NEPC and for its two major sub-groups [small cell carcinoma (SCC) and neuroendocrine carcinoma (NEC)]. Results: AAIR of NEPC continues to rise in recent years (2004-2011:+6.8%/year, p>0.05). AAIR of SCC has been increasing significantly by 6.94%/year since 2001 (from 0.470 to 0.582/1,000,000 person years, p<0.05). Overall incidence-based mortality rates for NEPC did not change significantly since 1992 and similar trends were observed for SCC and NEC. Conclusion: The AAIR of SCC is increasing with no change in the MR of NEPC over the past 20 years. ER -