TY - JOUR T1 - Significant Association of Cyclo-oxygenase 2 Genotypes with Upper Tract Urothelial Cancer JF - Anticancer Research JO - Anticancer Res SP - 2725 LP - 2730 VL - 35 IS - 5 AU - WEN-SHIN CHANG AU - CHENG-HSI LIAO AU - CHIN-MU HSU AU - CHUNG-YU HUANG AU - HSIN-YUAN FANG AU - PEI-YU KAO AU - CHIA-WEN TSAI AU - HSI-CHIN WU AU - PEI-SHIN HU AU - TZU-CHIA WANG AU - YUN-RU SYU AU - HAO-AI SHUI AU - DA-TIAN BAU Y1 - 2015/05/01 UR - http://ar.iiarjournals.org/content/35/5/2725.abstract N2 - Aim: Reliable biomarkers are in urgent need for diagnosis, outcome prediction and treatment-effect monitoring for upper tract urothelial carcinomas (UTUC). Although up-regulation of cyclo-oxygenase 2 (COX2) is found in stroma and tumor cells in more than half of the patients with UTUC investigated, the genomic contribution of COX2 to UTUC has not been studied. The study aimed to evaluate the association of six polymorphic genotypes of COX2 with UTUC within a Taiwanese population. Materials and Methods: A total of 218 patients with UTUC and 580 healthy controls were genotyped for six COX2 polymorphisms, namely A-1195G, G-765C, T+8473C, intron 1, intron 5 and intron 6, and examined for their association with UTUC risk. Results: The distribution of genotypes of COX2 G-765C and intron 5 were significantly different between patient and control groups (p=0.0001 and 0.0016, respectively), while others were not (p>0.05). The haplotype analysis showed that compared to the GG/TT haplotype of COX2 G-765C/intron 5, those carrying GG/AT variants have a significantly increased risk of UTUC (odds ratio=4.83, 95% confidence interval=1.79-13.06), while those carrying CG/TT variants have a decreased risk (odds ratio=0.26, 95% confidence interval=0.14-0.49). Conclusion: Our results suggest that individual and combined COX2 G-765C/intron 5 genotypes play a role in controlling COX2 expression and UTUC development. ER -