TY - JOUR T1 - Preliminary Results of a Multicentre Study of the UBC Rapid Test for Detection of Urinary Bladder Cancer JF - Anticancer Research JO - Anticancer Res SP - 2651 LP - 2655 VL - 35 IS - 5 AU - THORSTEN H. ECKE AU - CHRISTIAN ARNDT AU - CARSTEN STEPHAN AU - STEFFEN HALLMANN AU - OLIVER LUX AU - THOMAS OTTO AU - JÜRGEN RUTTLOFF AU - HOLGER GERULLIS Y1 - 2015/05/01 UR - http://ar.iiarjournals.org/content/35/5/2651.abstract N2 - Background/Aim: UBC Rapid is a test detecting fragments of cytokeratins 8 and 18 in urine. These are cytokeratins frequently overexpressed in tumor cells. We present the first results of a multi-centre study using UBC Rapid in patients with bladder cancer and healthy controls. Materials and Methods: Clinical urine samples from 92 patients with tumors of the urinary bladder (45 low-grade and 47 high-grade tumors) and from 33 healthy controls were used. Urine samples were analyzed by the UBC Rapid point-of-care (POC) system and evaluated both visually and quantitatively using a concile Omega 100 POC reader. For visual evaluation, different thresholds of band intensity for considering a test as positive were applied. Sensitivities and specificities were calculated by contingency analyses. Results: We found that pathological concentrations by UBC Rapid are detectable in urine of patients with bladder cancer. The calculated diagnostic sensitivity of UBC Rapid in urine was 68.1% for high-grade, but only 46.2% for low-grade tumors. The specificity was 90.9%. The area under the curve (AUC) after receiver-operated curve (ROC) analysis was 0.733. Pathological levels of UBC Rapid in urine are higher in patients with bladder cancer in comparison to the control group (p<0.0001). Conclusion: UBC rapid can differentiate between patients with bladder cancer and controls. Further studies with a greater number of patients will show how valuable these results are. ER -