%0 Journal Article %A MARIO BALDUCCI %A ROSA AUTORINO %A SILVIA CHIESA %A GIANCARLO MATTIUCCI %A ANGELO POMPUCCI %A LUIGI AZARIO %A GIUSEPPE ROBERTO D'AGOSTINO %A MILENA FERRO %A ALBA FIORENTINO %A SERGIO FERSINO %A CIRO MAZZARELLA %A CESARE COLOSIMO %A VINCENZO FRASCINO %A CARMELO ANILE %A VINCENZO VALENTINI %T Radiosurgery or Fractionated Stereotactic Radiotherapy plus Whole-brain Radioherapy in Brain Oligometastases: A Long-term Analysis %D 2015 %J Anticancer Research %P 3055-3059 %V 35 %N 5 %X Aim: To analyze the outcome of patients with brain oligometastases treated by radiosurgery (SRS) or fractionated stereotactic radiotherapy (FSRT) after whole-brain radiotherapy (WBRT). Patients and Methods: Overall survival (OS) and local control (LC) were evaluated in patients (patients) with 1-2 brain metastases. Results: Forty-seven patients were selected. They were submitted to WBRT (median dose=3,750 cGy) followed by SRS (17 patients; median dose=1,500 cGy) or FSRT (30 patients; median dose=2,000 cGy). Median follow-up was 102 months (range=17-151); the median survival was 22 months for the SRS group and 16 months for the FSRT group. One-year and 5-year survival was 56% and 16%, respectively, in SRT and 62.1% and 3%, respectively, in FSRT. Neither treatment proved to significantly impact OS (p=0.4). The 1-year LC rates were 80% and 61.1% in the two groups, respectively (p=0.15). Conclusion: SRS or FSRT after WBRT could offer the same outcomes in patients with brain oligometasteses. Further investigation is warranted to confirm these data and define the optimal stereotactic modality. %U https://ar.iiarjournals.org/content/anticanres/35/5/3055.full.pdf