PT - JOURNAL ARTICLE AU - YUKIHIRO YANO AU - TOMOYUKI OTSUKA AU - HIROSHI HIRANO AU - TAKESHI UENAMI AU - AKITOSHI SATOMI AU - MUNEYOSHI KUROYAMA AU - MANABU NIINAKA AU - TSUTOMU YONEDA AU - HIROMI KIMURA AU - MASAHIDE MORI AU - TOSHIHIKO YAMAGUCHI AU - SOICHIRO YOKOTA TI - Nuclear Survivin Expression in Small Cell Lung Cancer DP - 2015 May 01 TA - Anticancer Research PG - 2935--2939 VI - 35 IP - 5 4099 - http://ar.iiarjournals.org/content/35/5/2935.short 4100 - http://ar.iiarjournals.org/content/35/5/2935.full SO - Anticancer Res2015 May 01; 35 AB - Background/Aim: Little evidence exists regarding a relationship between survivin expression and prognosis in small cell lung cancer (SCLC). We investigated the relationship between survivin expression, clinical characteristics and prognosis in SCLC patients. Materials and Methods: We retrospectively reviewed medical records of study patients and analyzed their tumor sections using nuclear survivin labeling index (LI). Results: A significant correlation between nuclear survivin LI and clinical stage was found (p=0.012). In multivariate analysis, a significant association was found between survival and clinical stage (hazard ratio (HR)=2.09; 95 % confidence interval (CI)=1.08-4.31; p=0.027) but not between survival and nuclear survivin LI (HR=0.96; 95 % CI=0.91-1.02; p=0.2). Conclusion: We did not find any positive relationship between nuclear survivin expression and survival in SCLC patients. Conversely, we found a positive relationship between clinical stage and nuclear survivin LI, which is considered to be useful in deciding treatment strategies.