RT Journal Article
SR Electronic
T1 Inflammation-Related Tumor Progression in Murine Fibrosarcoma Exhibited Over-expression of Sex-determining Region Y-box 2 (Sox2) Compared to Parental Regressor Cells
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3217
OP 3221
VO 35
IS 6
A1 YASUHIRO KURAMITSU
A1 ISSEI TANAKA
A1 YUFENG WANG
A1 FUTOSHI OKADA
A1 KAZUHIRO TOKUDA
A1 TAKAO KITAGAWA
A1 JUNKO AKADA
A1 KAZUYUKI NAKAMURA
YR 2015
UL http://ar.iiarjournals.org/content/35/6/3217.abstract
AB Background/Aim: Tumor progression is one of the most serious issues to overcome cancer disease. As a model of inflammation-induced tumor progression, we used the regressive murine fibrosarcoma cell clone QR-32 and the progressive malignant clone QRsP-11, that was derived from QR-32. Heat shock protein beta-1 (Hspb1) is a molecular chaperone. Hspb1 plays roles in not only cell protection but also chemo-resistance, tumorigenicity and protection from apoptosis. In a recent study, we showed that Hspb1 was up-regulated in QRsP-11 compared to QR-32. Materials and Methods: We compared the expression levels of Hspb1, Hsf1 and Sox2 in QR-32 and QRsP-11 cells by means of western blotting. Results: Hsf1, a transcription factor for Hspb1 was not increased in QRsP-11. Sex determining region Y-box 2 (Sox2) is a transcription factor, reported to interact with Hspb1. Sox2 was up-regulated in QRsP-11 compared to QR-32. Conclusion: These results suggest that Sox2-Hspb1 signaling is a possible pathway responsible to tumor progression of QRsP-11.