TY - JOUR T1 - Inflammation-Related Tumor Progression in Murine Fibrosarcoma Exhibited Over-expression of Sex-determining Region Y-box 2 (Sox2) Compared to Parental Regressor Cells JF - Anticancer Research JO - Anticancer Res SP - 3217 LP - 3221 VL - 35 IS - 6 AU - YASUHIRO KURAMITSU AU - ISSEI TANAKA AU - YUFENG WANG AU - FUTOSHI OKADA AU - KAZUHIRO TOKUDA AU - TAKAO KITAGAWA AU - JUNKO AKADA AU - KAZUYUKI NAKAMURA Y1 - 2015/06/01 UR - http://ar.iiarjournals.org/content/35/6/3217.abstract N2 - Background/Aim: Tumor progression is one of the most serious issues to overcome cancer disease. As a model of inflammation-induced tumor progression, we used the regressive murine fibrosarcoma cell clone QR-32 and the progressive malignant clone QRsP-11, that was derived from QR-32. Heat shock protein beta-1 (Hspb1) is a molecular chaperone. Hspb1 plays roles in not only cell protection but also chemo-resistance, tumorigenicity and protection from apoptosis. In a recent study, we showed that Hspb1 was up-regulated in QRsP-11 compared to QR-32. Materials and Methods: We compared the expression levels of Hspb1, Hsf1 and Sox2 in QR-32 and QRsP-11 cells by means of western blotting. Results: Hsf1, a transcription factor for Hspb1 was not increased in QRsP-11. Sex determining region Y-box 2 (Sox2) is a transcription factor, reported to interact with Hspb1. Sox2 was up-regulated in QRsP-11 compared to QR-32. Conclusion: These results suggest that Sox2-Hspb1 signaling is a possible pathway responsible to tumor progression of QRsP-11. ER -