RT Journal Article
SR Electronic
T1 Impact of Stereotactic Radiosurgery Dose on Control of Cerebral Metastases from Renal Cell Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3571
OP 3574
VO 35
IS 6
A1 DIRK RADES
A1 STEFAN HUTTENLOCHER
A1 NIKLAS GEBAUER
A1 DAGMAR HORNUNG
A1 NGO THUY TRANG
A1 MAI TRONG KHOA
A1 STEVEN E. SCHILD
YR 2015
UL http://ar.iiarjournals.org/content/35/6/3571.abstract
AB Aim: Renal cell carcinoma (RCC) is a relatively radioresistant tumor and may require for higher radiation doses than other tumor types. Patients and Methods: Nineteen patients treated with 20 Gy of stereotactic radiosurgery (SRS) alone for one to three cerebral metastases were compared to nine patients treated with 16-18 Gy. Results: SRS with 20 Gy led to significantly better local control than did 16-18 Gy (81% vs. 50% at 12 months; p<0.001). Results were also significant on multivariate analysis (risk ratio: 6.30; p=0.033). SRS dose did not associate with freedom from new cerebral metastases (75% vs. 62% at 12 months; p=0.42) or survival (16% vs. 56% at 12 months; p=0.46). On multivariate analyses, better survival was associated with higher Karnofsky performance score (p<0.001) and absence of extracranial metastatic disease (p=0.006). Conclusion: In patients treated with SRS alone, local control of cerebral metastases from RCC was better after 20 Gy than after 16-18 Gy.